Thursday, April 1, 2010

Hot pakistan& Beautiful girl from Pakistan& Going Hot Pakistani Girls on Beach Pics

aPakistani girls are get famous by hot Pakistani girls on internet, but in fact Pakistani girls you see over net are not really all belongs to Pakistan. Most of these girls are belongs to Dubai and some Indian girls too labeled with Pakistani girls. Indeed some
of them really belongs to various cities of Pakistan like Lahore, Karachi, Islamabad. These are the modern girls having no bounds from here parents that’s why they are free to make their mobile clips or mms videos and photos to share on internet.
Some girls and Pakistani boys are giving their phone numbers on internet to get get friendship with Pakistani girls and boys. The second more common interest now develop in new generation of Pakistani girl i to wear sexy dresses but these girls also belongs to elite class , not common Pakistani girls are wearing such a hot and sexy cloths.
According to my observation friendship with Pakistani girls is somewhat fake because mostly boys there in Pakistan are using China mobile sets which have best voice changer built in functions. In this way boys are posting their cell numbers as pretending like a girl and with a female name, like Saira, Nazia, Mehwish etc. And some silly guys giving a short time to making contact at those fake numbers , in result they get fooled by voice changers and load mobile balance to fake girls.
You may search for any thing like Pakistani girls or actress wallpapers on internet and about 70 present of results you got are fake not real. So be conscious about searching such a thing on the Internet. Thank you for your time.Pakistani girls are doing extremely well in college education. According to the majority reports including from the HEC Pakistan, girls consistently outrank their male complement in the annual exams. From the matriculation, through to F.A. / FSC and all the way to Masters level, Pakistani girls are regularly out performing male students in almost all land of knowledge.
According to Noor 20 years old beautiful girls from Lahore Pakistan this may be due to the fact that girls are often more motivated to be independent in a patriarchal, male dominated society like Pakistan. This gives them added impetus to perform well in school and college in order to make better careers for What the fuss is all about? Every second person who have mobile in Pakistan is suffering from some kind of interruption from the wrong callers. Majority is of guys searching for girl’s mobile numbers. When they are asked, they reply that they only need to talk and sms and wants a sms friendship. What the heck is this !
Here in there there are many incidences occurring, here I am sharing one of mine.
Some time before this incident happened to me, I have a lot of friends, all are fond of forwarding nice messages and blurbs. I always contact my closed ones by typing their numbers instead of selecting from the contact book. So one day I sent my sms to a wrong number, here all fuss get started.
The wrong number was of some girl, she called me and inquired about me, who are you and here I got her number. In reply I simply told the truth, but she was’nt not ready to belive it, and abused me. I was only dump folded listening and adding some new bad sounded words in my dictionary.
Later on this all continues as she was not ready to believe and I was stuck to the truth. The gave me all references about her brother and uncles in ISI, Army, and his bro in some telecoms franchise ready to block my sim, but then a sudden stoppage in her sms came and I enjoyed my relief. My mind was totally out of her existence. Then after two weeks she become alive and started the sms convoy with a different tone altogether. She mentioned that she liked my voice, teased me and asked AM i burger type boy? or a normal junk. In short I was not ready for this all type of questions. She was also eager to talk with me on phone, which I accepted in order to tell her the consequences and what I planned for her.
I told her clearly that if again you disturbed me, Ill kick your number out and submit to spam authority of respective mobile company. So Did I, because she was not ready to agree.
In short, not only boys certain type of girls are practicing this habit at large. Don’t know how they are affording such a big risk.
Please share your similar experiences with us, to aware people about the righteous act to adopt at such instances.hotpakistanigirlsonbeacte1
hotpakistanigirl






Now Mobile Phone Numbers of Lahore Girls

Nobody is stopping you to dial a number on your mobile phone and chat to a Lahori girl from anywhere in the great Mughal empires city. If only you had their numbers, how you wish. You are spending some quality time on the internet searching for girls from Lahore who have their mobile phone numbers and pictures posted through MMS or other technologies. Please share lahori girls phone numbers and images. if you have liberty market girls from lahore mobile numbers.
Images are one thing and speaking live is another. So the next best thing is provided to you via these posts on the Blog.
Get your fix for the day and return whenever you wish. Please share mobile phone numbers in comments.

Islamic Concept of Human Rights chang ur life

~Kashish_Sanya~'s Avatar

Thanks to some developments across the globe for last few years, the universal values of great religion, Islam, have come in for denunciation. By invoking the actions of a few individual Muslims to typify the character and conduct of millions of adherents of this divine faith, efforts have been made to equate Islam with bigotry and obscurantism. This is most unfortunate at a time when the need for inter-faith dialogue and harmony could not be over-emphasized in order to bridge the gulf between Islam and West. The proponents of 'clash of civilizations' and their counterparts in the Islamic world are bent upon creating differences aimed at spreading confusion and misunderstanding about the teachings of Islam. In view of these circumstances, it is all the more necessary to bring the Islamic teachings in correct perspective to serve the cause of co-existence Islam so emphatically lays its stress on.

Let me start with concept of human rights in Islam. At the outset, it is to be understood very clearly that the basic concept of Islam in regard to the human rights is based upon equality, dignity and respect for humankind. As is clear from the Holy Quran, Allah Almighty has endowed on human beings the status of being superior to all other creations. The holy Quran has described the position enjoyed by the human beings in a great detail that at the time of creation of Huzrat Adam (RA), Allah Almighty enjoined upon the angels to bow before Huzat Adam (RA).

It was for the first time in the history of mankind that Islam did away with all biases and discriminations on the basis of wealth, clan and tribe, language, sex, colour and caste etc and termed all human beings equal in status whether one is poor or rich, black or white, woman or man or does one belong to this or that region or race. What greater example of human equality can there be that the people belonging to various countries, languages and races gather at the precincts of the holy Kabaa for worship and wear the same dress.

After laying the foundation of respect and equality of man, Islam prescribed a complete charter of rights for humanity ranging from moral rights to religious, economic, social and political rights. Islamic concept of human rights and freedoms is uniform and of universal character, which is independent of historical and regional boundaries of time and space. The Islamic concept of human rights originates from the commandments of Allah Almighty, which were conveyed to the Ummah through the Holy Prophet (PBUH).

The rights given by Allah are in the form of blessings and there is no role of any human effort in their acquirement. Contrary to the violable nature of rights given by the earthly law-makers, these rights are permanent, unchangeable, inviolable and sacred. Since Divine intent underlines them, therefore, they can not be suspended, amended or changed. In a real Islamic state, these rights are to be enjoyed by every citizen. Neither can any state nor an individual violate them.

Another unique feature of Islamic concept is that here rights and duties are interdependent and complement each other. That is why obligations and duties have equally been stressed upon as rights.

It is regrettable that while terming West torch-bearer of human rights, the contribution of Islam in ordaining these rights is ignored. The fact remains that the concept of human rights in the Western world in its present shape is not an old phenomenon. It dates back only to 16th and 17th centuries when political thinkers and legal experts presented the concepts of basic rights and civil freedoms.

The thoughts of these thinkers and philosophers in the West created unending conflict between the rulers and the ruled that led to struggle and clash between the imperialist forces and common people for achieving these freedoms and rights. A great advance was made in the realm of human rights when people of Great Britain got their rights through a series of legal documents namely Magna Carta (1215), Petition of Rights (1628) and Bill of Rights (1689). The people of France won their freedoms through Declaration of Rights right after the French Revolution in 1789. The USA got its freedom through war of independence in 1776. Its people achieved basic rights in 1791 in the form of Bill of Rights, which laid the foundation of first ten amendments in the American constitution. The modern nation-states have made the basic human rights the part of their respective constitutions under the influence of various UN conventions and Declarations.

Islam teaches moderation and balance in life. The teachings of the Holy Prophet (PBUH) provide a guarantee to create balance in life. This basic principle of Islam characterizes all of its teachings and commandments. The human rights granted by Islam bear the same stamp. No other social and political system can match that of Islam in its practicality, moral outlook and result-orientedness. The Islamic concept of rights is different from the philosophies of other systems in the following ways:

Islam preaches fulfillment of rights rather than demand of rights. The basic teaching of Islam is that every person is under obligation to realize the rights of others in every possible way. The society will become an ideal society where duty of one individual is the right of other. When people are engaged in the fulfillment of their rights with this consciousness, such societies become the paragon of respect for rule of law and human rights. The Holy Prophet (PBUH) has presented such a system of human rights, which has reciprocal relationship and proportionality between rights and duties. That means that no person will be justified in demanding his rights unless he performs his obligations. Since the main stress is laid on the performance of duties, therefore, no individual can raise his voice for rights as long as he does not perform his duties. Thus the rights stand fulfilled automatically in the process of performance of duties. The Islamic concept of human rights is comprehensive and compact in that it has proportion and balance between rights and duties. The lack of understanding of this basic concept has given rise to many confusions and misunderstandings. Islam has termed some matters to be duties not rights keeping in view their legal and social importance whose non-performance has been held as punishable act. For example bearing witness is obligatory on males. The transparent and effective system of evidence is a necessary element for the establishment of the rule of law in society. That is why our religion has held men responsible for bearing witness, while the women have been absolved of this responsibility owing to their natural biological difference. Now it is their right not duty. There is no doubt about the fact that Islam and West attach great importance to basic freedoms and human rights but their perspectives are basically different on the issue of human rights. The difference is explained in terms of their basic varying outlooks. Islam looks at human rights in the perspective of man's total obedience to Allah Almighty whereas the Western concept of human rights is totally secular, which is based on man's relations with the state as a citizen.

If analyzed broadly, the real difference is that in Islam, source of all powers is Allah Almighty, Who is the founder of all worlds. His commandments are the supreme law. Man is vicegerent of Allah on this earth. People are not repository of absolute powers. Rather they exercise these powers through their elected representatives within the limits set by Allah. The exercise of these powers is regarded as trust. Contrary to this, people are considered as source of all powers in secular, democratic societies of the West. The constitutions so framed by the representatives of people are accepted as supreme law of the land.

It is on the basis of this difference on the source of absolute powers that there are different perspectives of Islam and West on human rights. Islam makes a clear and comprehensive statement of civil freedoms and rights, which are inviolable and sacred. However law-making institutions of the Islamic state enjoy the rights of making amendments in these rights keeping in view the demands of the changing social, political and economic circumstances provided these modifications are in consonance with the spirit of the holy Quran, Sunnah and the Islamic law. Another important feature of these rights is that they have universal character and can be enjoyed both by Muslim and non-Muslim citizens.

On the other hand, the people in West have been able to achieve these rights after undertaking great protracted struggles. Moreover their successes on this front are a recent phenomenon and stand the chance of being reversed on this or that reason. In the third world countries, these rights do not enjoy any respect as they are only found in the statute books and not implemented. Here in these modern democratic countries, the scope of basic rights is limited not universal. The Vienna Declaration adopted at the International Conference on Human Rights in June 1993 stated:

"All human rights are universal, indivisible and interdependent and interrelated."

In spite of adopting this concept of human rights constitutionally, Article 10 of Human Rights Charter (2000) of European Union stated:

"Certain rights shall be reserved for citizens of the European Union."

The point being contended here is that certain rights are reserved for its citizens in West, which can by enjoyed neither by expatriates nor minorities. Various Declarations and Conventions adopted by the United Nations are no doubt universal but their implementation is not bound by any legal sanction.

To conclude it can be said that it is wrong to pick isolated example and incidents to typify the character of Islam. Islamic teachings and values are universal without any discrimination and biases of caste, creed, colour and religion.


beauti health & tips for urdu


Amid the busy lifestyles, long working hours, jam-packed schedules most of the times, most of us end up ignoring our health. So, to give you a wake-up call to rise healthier and live longer, we bring to you ten ways to live healthy....


Go for exercise Regular exercising helps in maintaining or gradually increasing the strength and endurance of heart and other muscles. An exercise program may include a variety of aerobic activities, such as walking, swimming and cycling. If one has a busy and sedentary lifestyle, a walk of 5 minutes after every hour is necessary.

Healthy eating - One may unlock the door to healthy life by eating healthy. Healthy eating never stands for eating less or dieting, but it’s all about eating a nutritious and a well balanced diet. A healthy diet is one which includes a good combination of fruits, vegetables, dairy products. One should go for 4-5 servings of fruits and vegetables per day to stay fit. If you are really interested in maintaining a good health, then prefer not to miss your breakfast because it provides with the energy or fuel required by the body after a gap of long night.

Go for water - Drink plenty of fresh water, to keep your body healthy. One can have 4 liters of liquid per day. (Heart patients who are on fluid restrictive diets, or have a problem with fluid retention should consult a physician before increasing their consumption of fluids)

Salt restriction - Modest salt restriction, which means limiting common salt intake to 6 grams per day, lowers the blood pressure. This effect is particularly important for those who have severe hypertension to begin with. They respond better to salt restriction. Salt restriction is also especially effective in elderly and obese hypertensive patients. The magnitude of reduction in the risk of stroke and coronary heart disease by salt restriction alone is estimated to be 22 percent and 16 percent respectively. Please note, a salt free diet is not advisable in most instances. In fact, very low salt intake may cause marked fall in blood pressure, leading to giddiness and transient impairment of consciousness. Salt restriction may be somewhat relaxed during peak summer when considerable loss of sodium may occur via sweating.

Sleep well - Having proper and apt sleep is one of the most important rationales to keep you fit and fine. It helps you to mark a provisional end to your fears and apprehensions. An adult should have a minimum sleep for 7-8 hours while a child should have 10 hours of sleep.

Maintain ideal weight - Carrying a lot of extra weight as fat can greatly affect your health and increases the risk of life-threatening conditions such as coronary heart disease and diabetes. One can easily calculate their ideal body weight through their Body Mass Index (BMI).
BMI = [Weight (in kilograms) / Height (in inches) * 2] * 703
If your BMI lies in the range of 19 to 25 it means you are healthy, below that range is underweight while from 25 29 is overweight and 30 means obese. If you are overweight or obese, start by making small, but healthy changes to what you eat, and try to become more active.

Manage your stress levels Hectic lifestyles accompanied with ever rising aspirations has become a major cause of stress in our lives. If not managed in a proper way, stress can give rise to emotional, physical, and psychological problems and can even take a toll on your heart. To manage stress one can opt for simple things which help in distressing like getting a pet in their lives, or sparing time for their hobbies, or playing with kids.

Monitor your blood pressure and cholesterol levels - People with high blood pressure run a higher risk of having a stroke or a heart attack. It is ideal to monitor the blood pressure daily and report if there is any change in the reading. Keeping blood pressure on the lower side helps to decrease the strain on the heart.

Keep a tab on your Alcohol intake It is observed that hypertension is more common in people who consume more than 1-2 ounces of alcohol every day. Heavy alcohol intake may increase the BP acutely. Increase in blood pressure may persist up to as long as 1 week after alcohol intake. Reduction in alcohol intake from 440 ml to 66 ml per day has been found to reduce systolic blood pressure by 5 mm Hg and diastolic pressure by 3 mm Hg. Therefore, hypertensive patients should avoid more than 1-2 drinks in a day. Some people, especially women may be more sensitive to alcohol. They should abstain from alcoholic drinks.

Go for preventive health checkups You do not need to go to doctor only for medical emergencies. In times of slow resistance, unhealthy lifestyles we should realize the importance of timely medical check-ups. We should be regular with our check-ups, before there is a serious condition
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breast cancer cells evade therapeutic attacks


Professor Didier Picard’s team in Switzerland uncovers a mechanism of resistance of tumour cells to the widespread treatment of the so-called hormone-dependent types

Tumour cells depend upon estrogens to survive and proliferate in about 70% of all breast cancer cases. The most frequently used treatment to fight this variety of tumours relies on anti-estrogens such as tamoxifen. However, resistance to this type of therapy develops in more than 30% of the patients. Understanding the mechanisms involved in the appearance of resistance to tamoxifen is thus essential to develop new therapeutic approaches. The research done by the team of Didier Picard, professor at the University of Geneva (UNIGE), provides key answers in the 1st of April 2010 edition of Genes & Development. Their study reveals how cancer cells become impervious to the drug by activating a specific biochemical cascade. The latter, normally triggered by a chemical messenger called cyclic AMP, is permanently stimulated in cells refractory to the treatment.
Breast cancer, which is characterized by an enhanced and anarchic proliferation of mammary cells, is one of the main causes of cancer-related mortality in women. In over two thirds of the cases, estrogens play an active part in the progression of the disease, due to the presence of receptors for this hormone in the nucleus of malignant cells. Estrogens indeed modulate the expression of genes necessary to cell survival and proliferation through their interaction with these receptors.
The most frequent treatment for this type of breast cancer, called hormone-dependent, relies on anti-estrogens such as tamoxifen, which block tumour cell growth by inhibiting the activity of the receptor. However, the cancer eventually becomes resistant to the therapy in more than 30% of the patients.
The second messenger’s key role
“Estrogen receptors, notably the one called ERI±, are also activated by other molecules that operate in an indirect way, without interacting with them”, explains Didier Picard, professor at the Faculty of Sciences of UNIGE. “We aim precisely at understanding the mechanisms involved in the indirect stimulation of ERI± in cancer cells”.
Researchers from his team have studied a molecule, cyclic AMP, which is able to convey various types of signals within the cell. Called a “second messenger”, this molecule acts as an intermediary to transmit information between the exterior and the interior of the cell. Different growth factors, neurotransmitters or hormones, incapable of crossing the cell barrier, thus communicate their message by activating intracellular signalling pathways via cyclic AMP.
A novel mode of regulation
“During this project, we have studied how cyclic AMP could turn on ERI± in breast cancer cells in the absence of estrogens”, says lead author Sophie Carascossa. In this case, the second messenger triggers a specific biochemical signalling cascade in which a protein called CARM1 is involved. The protein then binds ERI± and this in turn activates the receptor. “The interaction with CARM1 occurs in a domain of the receptor near the one that normally binds estrogens. This mode of regulation was completely unknown until now”, specifies the scientist. The study also reveals that the signalling pathway is stimulated in a constitutive way in malignant cells resistant to tamoxifen, thus evading control in these cells.
Although the molecular mechanisms implicated in the resistance process are probably numerous, the interaction between CARM1 and ERI± could represent a promising therapeutic target in the long run.

approach for rapid sexing embryo


The ability to determine animal gender could improve efficiency of animal production and animal selection. In dairy systems, sex determination would permit the specific production of either male or female embryos. In commercial dairy operations, female embryos of high genetic merit would be preferred for use as replacement stock. Artificial insemination organizations making planned matings would prefer males for their potential value as sires. A reliable method of sex determination is required for such a system.
Several methods have now been reported for mammalian sex determination as following: (i) Using polymerase chain reaction (PCR) to amplify a Y-chromosome-specific repeat sequence, DYZI, that is present 500-8000 times on the Y chromosome. The presence of this amplified target sequence indicates the presence of the Y-specific DNA sequence in the sample DNA and, hence, indicates that the animal is male. A disadvantage of this technique is that the absence of the amplified target sequence may be due either to the absence of the sequence in the sample DNA or to a failed reaction, (ii) Second method involves PCR-based genotyping. In brief, a pseudo-autosomal region (common to both X and Y chromosomes) present in both X and Y chromosomes is amplified. These homologous regions are called ZFY (in the Y chromosome) and ZFX (in the X chromosome). The amplified product is then digested with restriction enzymes that take advantage of restriction enzyme fragment length polymorphisms between ZFY and ZFX. The digested DNA is separated via electrophoresis. The ZFX and the ZFY DNA are identified by their different digestion patterns, (iii) Another PCR-mediated approach uses three sets of primers for sex determination of pre-implantation bovine embryos. As a positive control, the first set of primers amplifies a bovine-specific satellite DNA sequence. Thus, both male and female samples have this amplified target sequence. Two pairs of primers that recognize repetitive bovine Y-chromosome-specific sequences are then used in a PCR amplification reaction and (iv) Lastly and recently, novel technique was reported and developed. The main objective of our study is to develop improve in rapid sexing method for preimplantation embryos of bovine using loop-mediated isothermal amplification (LAMP) reaction. Embryo sexing has been recognized to control effectively the sex of offspring in the embryo transfer industry. This rapid and simple detection system was improved for bovine embryo sexing by adding ethidium bromide (EB) or CuSO4 at different concentrations to the product of LAMP reaction. The result of these additions was a colour change and a precipitate. It could be employed as an alternative method in the detection of the reaction products in place of the time consuming electrophoresis or the turbidity meter. This study showed that the present method can be applied in breeding programs to facilitate manipulation of the sex ratio of offspring. In conclusion, the present procedure without turbidity meter and electrophoresis was reliable and applicable for sexing both the bovine and buffalo embryos.
The sex determination assay developed in this study will be a useful adjunct to the technologies of embryo transfer and cloning. A sex determination assay of this kind will also facilitate scientific studies of gender differences in embryonic and fetal gene expression and development.



















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